There are
2,897 mi
from Irvine, CA to Holyoke, MA
That's the driving distance. It would take 2 days 4 hours to go from Irvine, California to Holyoke, Massachusetts.
The flight distance (direct flight from Irvine, CA to Holyoke, MA) is 2,500.48 mi.
2,897 mi = 3.22 kms