There are
356 mi
from Irvine, CA to Glendale, AZ
That's the driving distance. It would take 6 hours 30 mins to go from Irvine, California to Glendale, Arizona.
The flight distance (direct flight from Irvine, CA to Glendale, AZ) is 322.87 mi.
356 mi = 572.76 kms