There are
2,618 mi
from Irvine, CA to Gaithersburg, MD
That's the driving distance. It would take 1 day 23 hours to go from Irvine, California to Gaithersburg, Maryland.
The flight distance (direct flight from Irvine, CA to Gaithersburg, MD) is 2,269.27 mi.
2,618 mi = 3.22 kms