There are
2,386 mi
from Irvine, CA to Gainesville, FL
That's the driving distance. It would take 1 day 17 hours to go from Irvine, California to Gainesville, Florida.
The flight distance (direct flight from Irvine, CA to Gainesville, FL) is 2,094.11 mi.
2,386 mi = 3.22 kms