There are
1,845 mi
from Irvine, CA to Edwardsville, IL
That's the driving distance. It would take 1 day 8 hours to go from Irvine, California to Edwardsville, Illinois.
The flight distance (direct flight from Irvine, CA to Edwardsville, IL) is 1,584.72 mi.
1,845 mi = 2,968.96 kms