There are
1,818 mi
from Irvine, CA to Clayton, MO
That's the driving distance. It would take 1 day 7 hours to go from Irvine, California to Clayton, Missouri.
The flight distance (direct flight from Irvine, CA to Clayton, MO) is 1,563.95 mi.
1,818 mi = 2,925.38 kms