There are
2,091 mi
from Irvine, CA to Clarksville, IN
That's the driving distance. It would take 1 day 12 hours to go from Irvine, California to Clarksville, Indiana.
The flight distance (direct flight from Irvine, CA to Clarksville, IN) is 1,809.72 mi.
2,091 mi = 3.22 kms