There are
2,545 mi
from Irvine, CA to Charlottesville, VA
That's the driving distance. It would take 1 day 20 hours to go from Irvine, California to Charlottesville, Virginia.
The flight distance (direct flight from Irvine, CA to Charlottesville, VA) is 2,205.69 mi.
2,545 mi = 4,096.04 kms