There are
1,881 mi
from Irvine, CA to Cape Girardeau, MO
That's the driving distance. It would take 1 day 9 hours to go from Irvine, California to Cape Girardeau, Missouri.
The flight distance (direct flight from Irvine, CA to Cape Girardeau, MO) is 1,604.11 mi.
1,881 mi = 1.61 kms