There are
1,449 mi
from Iowa City, IA to Mesquite, NV
That's the driving distance. It would take 1 day 1 hour to go from Iowa City, Iowa to Mesquite, Nevada.
The flight distance (direct flight from Iowa City, IA to Mesquite, NV) is 1,247.85 mi.
1,449 mi = 1.61 kms