There are
361 mi
from Iowa City, IA to Cape Girardeau, MO
That's the driving distance. It would take 7 hours 6 mins to go from Iowa City, Iowa to Cape Girardeau, Missouri.
The flight distance (direct flight from Iowa City, IA to Cape Girardeau, MO) is 319.44 mi.
361 mi = 580.67 kms