There are
1,279 mi
from Independence, MO to Mesquite, NV
That's the driving distance. It would take 21 hours 57 mins to go from Independence, Missouri to Mesquite, Nevada.
The flight distance (direct flight from Independence, MO to Mesquite, NV) is 1,080.11 mi.
1,279 mi = 1.61 kms