There are
316 mi
from Huntsville, AL to Cape Girardeau, MO
That's the driving distance. It would take 6 hours 20 mins to go from Huntsville, Alabama to Cape Girardeau, Missouri.
The flight distance (direct flight from Huntsville, AL to Cape Girardeau, MO) is 241.87 mi.
316 mi = 508.66 kms