Miles between Hilton Head Island, SC and Picayune, MS

There are
644 mi
from Hilton Head Island, SC to Picayune, MS

That's the driving distance. It would take 12 hours 20 mins to go from Hilton Head Island, South Carolina to Picayune, Mississippi.

The flight distance (direct flight from Hilton Head Island, SC to Picayune, MS) is 539.25 mi.

644 mi = 1,036.85 kms