There are
1,025 mi
from Harlingen, TX to Sikeston, MO
That's the driving distance. It would take 19 hours 3 mins to go from Harlingen, Texas to Sikeston, Missouri.
The flight distance (direct flight from Harlingen, TX to Sikeston, MO) is 878.43 mi.
1,025 mi = 1,649.27 kms