There are
1,537 mi
from Harlingen, TX to San Marcos, CA
That's the driving distance. It would take 1 day 2 hours to go from Harlingen, Texas to San Marcos, California.
The flight distance (direct flight from Harlingen, TX to San Marcos, CA) is 1,261.17 mi.
1,537 mi = 2,473.85 kms