There are
2,286 mi
from Greenville, SC to Upland, CA
That's the driving distance. It would take 1 day 15 hours to go from Greenville, South Carolina to Upland, California.
The flight distance (direct flight from Greenville, SC to Upland, CA) is 1,998.27 mi.
2,286 mi = 3,679.19 kms