There are
2,339 mi
from Greenville, SC to Simi Valley, CA
That's the driving distance. It would take 1 day 17 hours to go from Greenville, South Carolina to Simi Valley, California.
The flight distance (direct flight from Greenville, SC to Simi Valley, CA) is 2,059.30 mi.
2,339 mi = 3,763.68 kms