Miles between Greenville, SC and Sikeston, MO

There are
544 mi
from Greenville, SC to Sikeston, MO

That's the driving distance. It would take 10 hours 29 mins to go from Greenville, South Carolina to Sikeston, Missouri.

The flight distance (direct flight from Greenville, SC to Sikeston, MO) is 426.26 mi.

544 mi = 875.85 kms