There are
2,490 mi
from Greenville, SC to Reno, NV
That's the driving distance. It would take 1 day 19 hours to go from Greenville, South Carolina to Reno, Nevada.
The flight distance (direct flight from Greenville, SC to Reno, NV) is 2,069.74 mi.
2,490 mi = 4,006.47 kms