There are
797 mi
from Greenville, SC to Poughkeepsie, NY
That's the driving distance. It would take 15 hours 24 mins to go from Greenville, South Carolina to Poughkeepsie, New York.
The flight distance (direct flight from Greenville, SC to Poughkeepsie, NY) is 658.94 mi.
797 mi = 1,282.52 kms