There are
776 mi
from Greenville, SC to Patchogue, NY
That's the driving distance. It would take 15 hours 30 mins to go from Greenville, South Carolina to Patchogue, New York.
The flight distance (direct flight from Greenville, SC to Patchogue, NY) is 654.34 mi.
776 mi = 1,249.56 kms