There are
2,289 mi
from Greenville, SC to Palmdale, CA
That's the driving distance. It would take 1 day 16 hours to go from Greenville, South Carolina to Palmdale, California.
The flight distance (direct flight from Greenville, SC to Palmdale, CA) is 2,017.94 mi.
2,289 mi = 3,683.04 kms