Miles between Greenville, SC and Cape Girardeau, MO

There are
550 mi
from Greenville, SC to Cape Girardeau, MO

That's the driving distance. It would take 10 hours 48 mins to go from Greenville, South Carolina to Cape Girardeau, Missouri.

The flight distance (direct flight from Greenville, SC to Cape Girardeau, MO) is 432.28 mi.

550 mi = 885.19 kms