There are
1,250 mi
from Greenville, SC to Amarillo, TX
That's the driving distance. It would take 22 hours 11 mins to go from Greenville, South Carolina to Amarillo, Texas.
The flight distance (direct flight from Greenville, SC to Amarillo, TX) is 1,098.13 mi.
1,250 mi = 2,011.63 kms