There are
1,546 mi
from Greenville, NC to Watertown, SD
That's the driving distance. It would take 1 day 4 hours to go from Greenville, North Carolina to Watertown, South Dakota.
The flight distance (direct flight from Greenville, NC to Watertown, SD) is 1,218.24 mi.
1,546 mi = 1.61 kms