There are
1,448 mi
from Greenville, NC to Sioux Falls, SD
That's the driving distance. It would take 1 day 3 hours to go from Greenville, North Carolina to Sioux Falls, South Dakota.
The flight distance (direct flight from Greenville, NC to Sioux Falls, SD) is 1,162.53 mi.
1,448 mi = 1.61 kms