There are
2,619 mi
from Greenville, NC to Poway, CA
That's the driving distance. It would take 1 day 22 hours to go from Greenville, North Carolina to Poway, California.
The flight distance (direct flight from Greenville, NC to Poway, CA) is 2,256.73 mi.
2,619 mi = 4,214.20 kms