There are
1,061 mi
from Greenville, NC to Opelousas, LA
That's the driving distance. It would take 19 hours 37 mins to go from Greenville, North Carolina to Opelousas, Louisiana.
The flight distance (direct flight from Greenville, NC to Opelousas, LA) is 920.19 mi.
1,061 mi = 1,706.99 kms