There are
667 mi
from Greensboro, NC to Sikeston, MO
That's the driving distance. It would take 12 hours 25 mins to go from Greensboro, North Carolina to Sikeston, Missouri.
The flight distance (direct flight from Greensboro, NC to Sikeston, MO) is 546.84 mi.
667 mi = 1,074.06 kms