There are
1,618 mi
from Great Falls, MT to Sikeston, MO
That's the driving distance. It would take 1 day 4 hours to go from Great Falls, Montana to Sikeston, Missouri.
The flight distance (direct flight from Great Falls, MT to Sikeston, MO) is 1,324.91 mi.
1,618 mi = 2,603.70 kms