There are
355 mi
from Glendale, AZ to Irvine, CA
That's the driving distance. It would take 6 hours 32 mins to go from Glendale, Arizona to Irvine, California.
The flight distance (direct flight from Glendale, AZ to Irvine, CA) is 322.87 mi.
355 mi = 570.62 kms