There are
1,249 mi
from Gaithersburg, MD to Sioux Falls, SD
That's the driving distance. It would take 23 hours 2 mins to go from Gaithersburg, Maryland to Sioux Falls, South Dakota.
The flight distance (direct flight from Gaithersburg, MD to Sioux Falls, SD) is 1,053.40 mi.
1,249 mi = 2,010.84 kms