There are
514 mi
from Gaithersburg, MD to Simpsonville, SC
That's the driving distance. It would take 9 hours 57 mins to go from Gaithersburg, Maryland to Simpsonville, South Carolina.
The flight distance (direct flight from Gaithersburg, MD to Simpsonville, SC) is 412.83 mi.
514 mi = 827.04 kms