There are
1,207 mi
from Gaithersburg, MD to Opelousas, LA
That's the driving distance. It would take 22 hours 18 mins to go from Gaithersburg, Maryland to Opelousas, Louisiana.
The flight distance (direct flight from Gaithersburg, MD to Opelousas, LA) is 1,030.22 mi.
1,207 mi = 1,943.08 kms