There are
376 mi
from Gaithersburg, MD to Holyoke, MA
That's the driving distance. It would take 7 hours 52 mins to go from Gaithersburg, Maryland to Holyoke, Massachusetts.
The flight distance (direct flight from Gaithersburg, MD to Holyoke, MA) is 320 mi.
376 mi = 605.84 kms