There are
1,223 mi
from Gainesville, FL to Waterloo, IA
That's the driving distance. It would take 22 hours 58 mins to go from Gainesville, Florida to Waterloo, Iowa.
The flight distance (direct flight from Gainesville, FL to Waterloo, IA) is 1,047.15 mi.
1,223 mi = 1.61 kms