There are
1,450 mi
from Gainesville, FL to Vermillion, SD
That's the driving distance. It would take 1 day 2 hours to go from Gainesville, Florida to Vermillion, South Dakota.
The flight distance (direct flight from Gainesville, FL to Vermillion, SD) is 1,215.18 mi.
1,450 mi = 1.61 kms