Miles between Gainesville, FL and Orangeburg, SC

There are
315 mi
from Gainesville, FL to Orangeburg, SC

That's the driving distance. It would take 6 hours 2 mins to go from Gainesville, Florida to Orangeburg, South Carolina.

The flight distance (direct flight from Gainesville, FL to Orangeburg, SC) is 279.06 mi.

315 mi = 507.22 kms