There are
2,187 mi
from Gainesville, FL to Mesquite, NV
That's the driving distance. It would take 1 day 16 hours to go from Gainesville, Florida to Mesquite, Nevada.
The flight distance (direct flight from Gainesville, FL to Mesquite, NV) is 1,890.39 mi.
2,187 mi = 3.22 kms