There are
1,182 mi
from Gainesville, FL to Manitowoc, WI
That's the driving distance. It would take 22 hours 39 mins to go from Gainesville, Florida to Manitowoc, Wisconsin.
The flight distance (direct flight from Gainesville, FL to Manitowoc, WI) is 1,039.53 mi.
1,182 mi = 1.61 kms