Miles between Gainesville, FL and Lancaster, SC

There are
412 mi
from Gainesville, FL to Lancaster, SC

That's the driving distance. It would take 7 hours 55 mins to go from Gainesville, Florida to Lancaster, South Carolina.

The flight distance (direct flight from Gainesville, FL to Lancaster, SC) is 361.80 mi.

412 mi = 662.26 kms