There are
1,145 mi
from Gainesville, FL to Holyoke, MA
That's the driving distance. It would take 22 hours 17 mins to go from Gainesville, Florida to Holyoke, Massachusetts.
The flight distance (direct flight from Gainesville, FL to Holyoke, MA) is 1,021.75 mi.
1,145 mi = 1.61 kms