Miles between Gainesville, FL and Greenville, SC

There are
452 mi
from Gainesville, FL to Greenville, SC

That's the driving distance. It would take 8 hours 30 mins to go from Gainesville, Florida to Greenville, South Carolina.

The flight distance (direct flight from Gainesville, FL to Greenville, SC) is 359.38 mi.

452 mi = 727.10 kms