There are
784 mi
from Gainesville, FL to Cape Girardeau, MO
That's the driving distance. It would take 14 hours 50 mins to go from Gainesville, Florida to Cape Girardeau, Missouri.
The flight distance (direct flight from Gainesville, FL to Cape Girardeau, MO) is 671.48 mi.
784 mi = 1,261.42 kms