There are
675 mi
from Fort Wayne, IN to South Sioux City, NE
That's the driving distance. It would take 12 hours 56 mins to go from Fort Wayne, Indiana to South Sioux City, Nebraska.
The flight distance (direct flight from Fort Wayne, IN to South Sioux City, NE) is 588.27 mi.
675 mi = 1,087.01 kms