There are
1,084 mi
from Fort Lauderdale, FL to Sikeston, MO
That's the driving distance. It would take 20 hours 2 mins to go from Fort Lauderdale, Florida to Sikeston, Missouri.
The flight distance (direct flight from Fort Lauderdale, FL to Sikeston, MO) is 927.14 mi.
1,084 mi = 1.61 kms