There are
1,434 mi
from Florence, SC to Sioux Falls, SD
That's the driving distance. It would take 1 day 2 hours to go from Florence, South Carolina to Sioux Falls, South Dakota.
The flight distance (direct flight from Florence, SC to Sioux Falls, SD) is 1,113.57 mi.
1,434 mi = 2,307.02 kms