There are
326 mi
from Fayetteville, AR to Sikeston, MO
That's the driving distance. It would take 6 hours 40 mins to go from Fayetteville, Arkansas to Sikeston, Missouri.
The flight distance (direct flight from Fayetteville, AR to Sikeston, MO) is 260.02 mi.
326 mi = 525.18 kms