There are
503 mi
from Fayetteville, AR to Opelousas, LA
That's the driving distance. It would take 9 hours 25 mins to go from Fayetteville, Arkansas to Opelousas, Louisiana.
The flight distance (direct flight from Fayetteville, AR to Opelousas, LA) is 400.36 mi.
503 mi = 808.93 kms